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Because glutathione is the major intracellular antioxidant defense within a cell, it is proposed that its depletion might be a prerequisite for modulating the apoptotic machinery in autoimmune disease like SLE (Figure 6)

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In another small study in healthy men with cardiovascular risk factors, those with abnormal reactive hyperemia index (RHI) which measures peripheral endothelial function and stiffness, experienced a significant reduction in arterial stiffness after taking sublingual glutathione