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doi: 10.3892/ijo.23.5.1317 117 ShimakuraSBolandCR

While specific therapies for IBM are still lacking, NAD + boosters have shown promising results in various models, including nematodes with amyloid aggregation, aged rodents, and human muscle cells from IBM patients

Spectroscopic and computational studies on the adenosylcobalamin-dependent methylmalonyl-CoA mutase: Evaluation of enzymatic contributions to Co-C bond activation in the Co3 + ground state

We found that niacin intake can elevate blood NAD + levels to a maximum of 80-120 M, a four to six-fold increase from normal levels, reaching a plateau in blood with daily doses of 500-750 mg