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Fresh tissue damage still has the cellular machinery for repair actively engaged, while chronic injuries may have entered a degenerative plateau
& Kashihara, N
Cancer 101 , 12531260 (2009)
Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation
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