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How the Combination Is Titrated in Practice When starting the combination, phentermine is typically introduced first to evaluate its effect on appetite control and ensure cardiovascular stability

However, these over-the-counter products are not FDA-approved medications and contain no actual GLP-1 receptor agonists

For a closer look at that adjustment period, see our guides on starting Ozempic in your first week and the typical Ozempic nausea timeline

Dietary and Lifestyle Changes That May Help Reducing high-sulphur and high-fat foods, eating smaller regular meals, staying hydrated, and keeping a food and symptom diary are practical dietary strategies that may reduce retatrutide-related digestive discomfort