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34,35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36,37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38,39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals

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doi: 10.1016/j.cell.2020.09.033 46 CoricV.MilosevicI.DjukicT.BukumiricZ.Savic-RadojevicA.MaticM.et al

D64.9 applies only when no specific type or cause is documented, and payers scrutinize it more than cause-specific codes