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It is because there are no clinical trial data to inform a recommendation either way

and Mayo, L.M., "GLP-1 receptor agonists for the treatment of alcohol use disorder," Journal of Clinical Investigation, May 1, 2025, doi: 10.1172/JCI192414 Hendershot, C.S., et al, "Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial," JAMA Psychiatry, April 1, 2025, doi: 10.1001/jamapsychiatry.2024.4789 Wang, W., et al, "Association of Semaglutide With Tobacco Use Disorder in Patients With Type 2 Diabetes : Target Trial Emulation Using Real-World Data," Annals of Internal Medicine, Aug

Sex differences in acetaminophen-induced acute liver injury and acute liver failure