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Aspalathin, a C-Glucosyl Dihydrochalcone from Rooibos Improves the Hypoglycemic Potential of Metformin in Type 2 Diabetic (Db/db) Mice

In addition, stem-like features can be acquired de novo by non-CSCs in response to environmental stimuli such as hypoxia, inflammation, or therapeutic pressure, indicating that CSCs may represent a dynamic functional state rather than a static subpopulation