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N-acetyl cysteine inhibits lipopolysaccharide-mediated synthesis of interleukin-1 and tumor necrosis factor- in human periodontal ligament fibroblast cells through nuclear factor-kappa B signaling

Seleninic or selenol intermediates generated from the oxidation/reduction of DSePA can follow the analogous catalytic steps as discussed for the native GPx enzyme in the earlier section to detoxify the hyperoxides by consuming the thiols [82, 83]

Methods Enzymol 401:408425 Janky R, Cruz-Aguado R, Oja SS, Shaw CA (2007) Glutathione in the nervous system: roles in neural function and health and implications for neurological disease