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8 When APAP is administered at therapeutic doses under normal physiological conditions, the remaining 510% of the drug is metabolized in hepatocytes by cytochrome P450 enzymes such as CYP2E1 and CYP1A2 through phase I enzymatic reactions, resulting in the generation of the toxic reactive metabolite NAPQI (Fig

Shelkar, G

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Researchers believe its potential benefits may stem from effects on oxidative stress, inflammation, and insulin sensitivity.13 Recent meta-analyses have reported improvements in several metabolic markers, while newer clinical studies suggest NAC may also support ovulation-induction outcomes in some women.20 21 People seeking fertility support Oxidative stress can affect both male and female fertility, which has led researchers to investigate NAC in several reproductive settings.32 In men, NAC combined with selenium has been shown to improve certain semen parameters.23 In women, NAC has been studied alongside IVF and other fertility interventions, with some research suggesting possible benefits for reproductive outcomes.24 Adults interested in healthy aging Interest in NAC has also expanded into healthy-aging research because of its role in glutathione production