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Retatrutide is an investigational triple incretin receptor agonist targeting GLP-1, GIP, and glucagon receptors to reduce appetite and body weight, while tesamorelin is a growth hormone-releasing hormone analogue that stimulates pituitary GH release to reduce visceral fat, primarily in HIV-positive patients with lipodystrophy

The advocacy campaign has backing from Eli Lilly, the manufacturer of Wegovy, according to a news release from AWHP

except for the placenta and the hypophysis that are particularly rich

Bottom line: Most body aches associated with GLP-1 use are preventable or manageable through proactive hydration, high protein intake, and consistent movement