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The physiological role of ghrelin in the regulation of energy and glucose homeostasis
[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance
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Likewise, minority and low-income youths have been underrepresented in trials, so we lack evidence on GLP-1 RA effects across diverse racial/ethnic groups
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