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At the level of body composition, limited DEXA and CT evidence suggests that GLP-1RAs primarily reduce fat massspecifically visceral fatwhile relatively preserving lean mass (54, 75)

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To be eligible patients must have: A Body Mass Index (BMI) of 40 or more AND Have been diagnosed with AT LEAST FOUR of the following: High blood pressure High cholesterol or abnormal blood fats Sleep apnoea Heart disease Type 2 diabetes For more details on who will become eligible over the coming years, see page 7 of the official NHS Guidance

Nature Neurosci ence 21(6):811-819