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It is structurally designed to interact with metabolic enzyme pathways and has become a subject of interest in metabolic and mitochondrial research fields

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Oxidative phosphorylation efficiency and ATP production change[8]

GH replacement using physiologic doses of 0.21.0 mg/day (estimated range for an 80 kg person based on various units used to report dosing regimens among studies) in this setting is associated with improvements in body composition (increases in lean mass and decreases in fat mass) in some studies (Bengtsson, Eden, Lonn et al., 1993, Salomon, Cuneo, Hesp et al., 1989, Snel, Brummer, Doerga et al., 1995, Lonn, Johansson, Sjostrom et al., 1996, Jorgensen, Thuesen, Muller et al., 1994, Woodhouse, Asa, Thomas et al., 1999, Blackman, Sorkin, Munzer et al., 2002), although other reports looking directly at muscle cross sectional area showed no changes over a 6-month period (Cuneo, Salomon, Mcgauley et al., 1992)