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Conclusion The results from aforementioned studies along with fomepizoles very high safety and low adverse effect profile have led medical toxicologists to use fomepizole for treatment of selected APAP OD patients (also receiving NAC), both early and late in their courses of illnesses, but without the benefit of results from clinical trials examining effectiveness

Van Goor H, van den Born JC, Hillebrands JL, Joles JA