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Compared to cytosolic NADK (cNADK), mitochondrial NADK (mNADK) has a distinctive feature that it can directly phosphorylate nicotinamide adenine dinucleotide (NADH) to generate NADPH to alleviate oxidative stress in mitochondria

Centromeric inactivation during aging can lead to chromosome segregation defects, genomic instability and decreased cell proliferation, which has become an important driver of aging

However, the initial FDA submission is for obesity only