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Attention Deficit/Hyperactivity Disorder (ADHD) Attention Deficit/Hyperactivity Disorder (ADHD) Last Section Update: 12/2023 Contributor(s) : Carrie Decker, ND, MS

It has emerged as a particularly relevant anti-inflammatory peptide due to an unusual property: oral bioavailability via the PepT1 intestinal transporter

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Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R