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The cardiac benefits of GLP-1 agonists were not anticipated before outcome studies were performed for several reasons: (1) Historical Precedent-past experiences with other diabetes medications that unexpectedly had adverse cardiovascular effects made it less likely for researchers and clinicians to anticipate potential cardiovascular benefits without concrete evidence from large-scale trials

PQQ and cardiovascular health The development of pulmonary hypertension (PH) is influenced by inflammation, an overabundance of pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs), and disruptions in mitochondrial and metabolic functions (Perez, 2016

This table shows the numbers and proportions of participants with experience of serious adverse events, categorised by system organ classes, regardless of treatment