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Dimethyl fumarate (DMF), as an activator of NF-E2-related factor 2 (NRF2), leads to the upregulation of IB and suppression of NF-B signaling pathway activation, thereby promoting the expression of key ferroptosis factors heme oxygenase 1 (HMOX1), NADPH quinone oxidoreductase 1 (NQO1), and GPX4

Studies show that patients taking GLP-1 medications often experience systolic and diastolic blood pressure improvements alongside weight loss, suggesting a connection between the medication class and heart health outcomes